Jakten på biomarkører

Jeg kom nettopp over en liten 3-minutters video, som på vakkert og enkelt vis forklarer en studie fra 2009; Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients, but not in normal subjects. (Light, White, Hughen, Light) Den viser også med all tydelighet hvor ekstremt en ME-syk reagerer på aktivitet.

Her er videoen:

Det ser ut som de har gjort en lignende undersøkelse i 2012; Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrom and Fibromyaligia Syndrome. (Light, Bateman, Hughen, Vanhaitsma, White, Light.)

Konklusjon: «At least two subgroups of patients with CFS can be identified by gene expression changes following exercise. The larger subgroup showed increases in mRNA for sensory and adrenergic receptors and a cytokine. The smaller subgroup contained most of the patients with CFS with orthostatic intolerance, showed no postexercise increases in any gene and was defined by decreases in mRNA for α-2A. FM-only patients can be identified by baseline increases in three genes. Postexercise increases for four genes meet published criteria as an objective biomarker for CFS and could be useful in guiding treatment selection for different subgroups.»

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